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Columbia UniversityThe President's Report 2002-2007
Groundbreaking Work
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Ronald Breslow (Chemistry)

Synthesis of new cancer-fighting compounds.

Ronald Breslow has been instrumental in synthesizing some 1,000 new chemical compounds that fight cancer, among these SAHA (suberoylanilide hydroxamic acid). SAHA induces cancer cells to transform into normal cells or commit suicide by inhibiting enzymes that are known to silence certain genes that allow tumor cells to proliferate when left unchecked. SAHA successfully completed clinical trials and has been approved as a new cancer chemotherapy.
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