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Columbia UniversityThe President's Report 2002-2007
Groundbreaking Work
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Lawrence Shapiro (Biomedical)

Workings of key metabolic enzyme unraveled, a boon for diabetes/obesity research

Lawrence Shapiro, a member of the Naomi Berrie Diabetes Center, uses X-ray crystallography to study the mechanism of proteins implicated in diabetes and obesity. The Shapiro lab recently determined atomic-level, three-dimensional structures of the AMP-activated protein kinase, a central regulator of energy homeostasis in all eukaryotic cells and an exciting potential therapeutic target for diabetes and obesity.
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