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Columbia UniversityThe President's Report 2002-2007
Groundbreaking Work
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Andrew Marks, Departments of Physiology and Medicine (Biomedical)

A defect in calcium channels has been found to be associated with heart failure. This discovery may guide future heart-attack treatment research.

Andrew Marks of the Departments of Physiology and Medicine has made a major contribution in the molecular biology of heart failure. He has found that the calcium release channel known as the ryanodine receptor becomes defective in heart failure. Detailed analysis of the receptor has led to the generation of new candidate drugs that effectively treat heart failure in animal models of the disease.
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